Book Chapter

Pyroptosis

KE Lawlor, S Conos, JE Vince

Apoptosis and Beyond: The Many Ways Cells Die | Published : 2018

Abstract

Pyroptosis is considered an inflammatory cell death pathway that can be triggered by caspase-1 or caspase-11, or the human caspase-11 orthologs, caspase-4 and caspase-5. The activation of caspase-1 is mediated by supramolecular cytosolic protein complexes, termed inflammasomes, which sense specific pathogen, host or environmental danger molecules. Prior to causing pyroptotic death, caspase-1 can also cleave and thereby activate the potent pro-inflammatory cytokines, interleukin-1 (IL-1) and IL-18. In contrast, the activation of caspase-11 is caused by its direct binding to cytosolic lipopolysaccharide (LPS) derived from gram-negative bacteria. While caspase-11 can promote caspase-1 activity,..

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