Journal article

The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ

Michael S Toss, Islam M Miligy, Rita Haj-Ahmad, Kylie L Gorringe, Abdulbaqi AlKawaz, Karuna Mittal, Ian O Ellis, Andrew R Green, Emad A Rakha

Histopathology | WILEY | Published : 2019


AIMS: Cathepsin A (CTSA) is a key regulatory enzyme for galactoside metabolism. Additionally, it has a distinct proteolytic activity and plays a role in tumour progression. CTSA is differentially expressed at the mRNA level between breast ductal carcinoma in situ (DCIS) and invasive breast carcinoma (IBC). In this study, we aimed to characterise CTSA protein expression in DCIS and evaluate its prognostic significance. METHODS AND RESULTS: A large cohort of DCIS [n = 776 for pure DCIS and n = 239 for DCIS associated with IBC (DCIS/IBC)] prepared as a tissue microarray was immunohistochemically stained for CTSA. High CTSA expression was observed in 48% of pure DCIS. High expression was associa..

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