Journal article
Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging
A Griffa, PS Baumann, P Klauser, E Mullier, M Cleusix, R Jenni, MP van den Heuvel, KQ Do, P Conus, P Hagmann
Translational Psychiatry | SPRINGERNATURE | Published : 2019
Abstract
Early in the course of psychosis, alterations in brain connectivity accompany the emergence of psychiatric symptoms and cognitive impairments, including processing speed. The clinical-staging model is a refined form of diagnosis that places the patient along a continuum of illness conditions, which allows stage-specific interventions with the potential of improving patient care and outcome. This cross-sectional study investigates brain connectivity features that characterize the clinical stages following a first psychotic episode. Structural brain networks were derived from diffusion-weighted MRI for 71 early-psychosis patients and 76 healthy controls. Patients were classified into stage II ..
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Awarded by Fondation Leenaards
Funding Acknowledgements
This work was supported by the Leenaards foundation (P.S.B.); the Swiss National Science Foundation (SNSF #310030-156874 (P.H., A.G.), #P2ELP3_ 172087 (A.G.)); the NCCR-Synapsy (#51AU40-125759 (P.H., A.G.)).