Journal article

Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging

Alessandra Griffa, Philipp S Baumann, Paul Klauser, Emeline Mullier, Martine Cleusix, Raoul Jenni, Martijn P van den Heuvel, Kim Q Do, Philippe Conus, Patric Hagmann

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Early in the course of psychosis, alterations in brain connectivity accompany the emergence of psychiatric symptoms and cognitive impairments, including processing speed. The clinical-staging model is a refined form of diagnosis that places the patient along a continuum of illness conditions, which allows stage-specific interventions with the potential of improving patient care and outcome. This cross-sectional study investigates brain connectivity features that characterize the clinical stages following a first psychotic episode. Structural brain networks were derived from diffusion-weighted MRI for 71 early-psychosis patients and 76 healthy controls. Patients were classified into stage II ..

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