Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging
Alessandra Griffa, Philipp S Baumann, Paul Klauser, Emeline Mullier, Martine Cleusix, Raoul Jenni, Martijn P van den Heuvel, Kim Q Do, Philippe Conus, Patric Hagmann
TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2019
Early in the course of psychosis, alterations in brain connectivity accompany the emergence of psychiatric symptoms and cognitive impairments, including processing speed. The clinical-staging model is a refined form of diagnosis that places the patient along a continuum of illness conditions, which allows stage-specific interventions with the potential of improving patient care and outcome. This cross-sectional study investigates brain connectivity features that characterize the clinical stages following a first psychotic episode. Structural brain networks were derived from diffusion-weighted MRI for 71 early-psychosis patients and 76 healthy controls. Patients were classified into stage II ..View full abstract
Awarded by Swiss National Science Foundation (SNSF)
Awarded by NCCR-Synapsy
This work was supported by the Leenaards foundation (P.S.B.); the Swiss National Science Foundation (SNSF #310030-156874 (P.H., A.G.), #P2ELP3_ 172087 (A.G.)); the NCCR-Synapsy (#51AU40-125759 (P.H., A.G.)).