Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats
Marcelo Flores-Opazo, Jennifer Trieu, Timur Naim, Denisse Valladares-Ide, Hermann Zbinden-Foncea, David Stapleton
INTERNATIONAL JOURNAL OF OBESITY | NATURE PUBLISHING GROUP | Published : 2020
BACKGROUND: Obesity is associated with development of insulin resistance in adipose tissue (AT). Human obesity has been associated with increased glycogen deposition in adipocytes. Adipocytes synthesise glycogen prior to the formation of lipids. The present study examined adipose glycogen content in obese Zucker rats and the effect of fasting on glycogen-metabolising enzymes. We hypothesised that obesity imposes a blunted response to fasting through impaired activation of glycogen-metabolizing enzymes, which dampens glycogen mobilization in obese Zucker rats. METHODS: We investigated the effect of 24h fasting on AT glycogen metabolism in 12-week old obese Zucker rats. Epididymal fat pads wer..View full abstract
MFO was granted by the Becas Chile scholarship program of CONYCIT.