GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes.

Y-B Chen; T Wang; MT Hemmer; C Brady; DR Couriel; A Alousi; J Pidala; A Urbano-Ispizua; SW Choi; T Nishihori; T Teshima; Y Inamoto; B Wirk; DI Marks; H Abdel-Azim; L Lehmann; L Yu; M Bitan; MS Cairo; M Qayed; R Salit; RP Gale; R Martino; S Jaglowski; A Bajel; B Savani; H Frangoul; ID Lewis; J Storek; M Askar; MA Kharfan-Dabaja; M Aljurf; O Ringden; R Reshef; RF Olsson; S Hashmi; S Seo; TR Spitzer; ML MacMillan; A Lazaryan; SR Spellman; M Arora; CS Cutler

Journal article

GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes.

Y-B Chen, T Wang, MT Hemmer, C Brady, DR Couriel, A Alousi, J Pidala, A Urbano-Ispizua, SW Choi, T Nishihori, T Teshima, Y Inamoto, B Wirk, DI Marks, H Abdel-Azim, L Lehmann, L Yu, M Bitan, MS Cairo, M Qayed Show all

Bone Marrow Transplant | Published : 2017

DOI: 10.1038/bmt.2016.265

Abstract

Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we analyzed 1404 umbilical cord blood transplantation (UCBT) patients (single (<18 years)=810, double (⩾18 years)=594) with acute leukemia to define the incidence of acute GvHD (aGvHD) and chronic GvHD (cGvHD), analyze clinical risk factors and investigate outcomes. After single UCBT, 100-day incidence of grade II-IV aGvHD was 39% (95% confidence interval (CI), 36-43%), grade III-IV aGvHD was 18% (95% CI, 15-20%) and 1-year cGvHD was 27% (95% CI, 24-30%). After double UCBT, 100-day incidence of grade II-IV aGvHD was 45% (95% CI, 41-49%), grade III-IV aGvHD was 22% (95% CI, 19-26%) and 1-year cGvHD was ..

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