Journal article

GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes.

Y-B Chen, T Wang, MT Hemmer, C Brady, DR Couriel, A Alousi, J Pidala, A Urbano-Ispizua, SW Choi, T Nishihori, T Teshima, Y Inamoto, B Wirk, DI Marks, H Abdel-Azim, L Lehmann, L Yu, M Bitan, MS Cairo, M Qayed Show all

Bone Marrow Transplant | Published : 2017

Abstract

Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we analyzed 1404 umbilical cord blood transplantation (UCBT) patients (single (<18 years)=810, double (⩾18 years)=594) with acute leukemia to define the incidence of acute GvHD (aGvHD) and chronic GvHD (cGvHD), analyze clinical risk factors and investigate outcomes. After single UCBT, 100-day incidence of grade II-IV aGvHD was 39% (95% confidence interval (CI), 36-43%), grade III-IV aGvHD was 18% (95% CI, 15-20%) and 1-year cGvHD was 27% (95% CI, 24-30%). After double UCBT, 100-day incidence of grade II-IV aGvHD was 45% (95% CI, 41-49%), grade III-IV aGvHD was 22% (95% CI, 19-26%) and 1-year cGvHD was ..

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