Utility-weighted modified Rankin Scale: Still too crude to be a truly patient-centric primary outcome measure?
Venesha Rethnam, Julie Bernhardt, Helen Dewey, Marj Moodie, Hannah Johns, Lan Gao, Janice Collier, Fiona Ellery, Leonid Churilov, undefined AVERT Trial Collaboration Group
International Journal of Stroke | Published : 2019
BACKGROUND: The utility-weighted modified Rankin Scale (UW-mRS) is an outcome measure recently proposed to improve statistical efficiency and interpretability of the mRS. Statistical properties of the UW-mRS have been well investigated, but construct validity has yet to be established. AIMS: To investigate the construct validity of the UW-mRS as a primary outcome measure by assessing variability in utility values within and between mRS categories, over time post-stroke, and by different derivation methods. METHODS: UW-mRS was derived using assessment of quality of life (AQoL-4D) and mRS scores at 3 and 12 months ( n = 2030) from a large randomized controlled trial, A Very Early Rehabilitatio..View full abstract