Journal article

Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival

Shehara Mendis, Sophie Beck, Belinda Lee, Margaret Lee, Rachel Wong, Suzanne Kosmider, Jeremy Shapiro, Desmond Yip, Simone Steel, Louise Nott, Ross Jennens, Lara Lipton, Matthew Burge, Kathryn Field, Sumitra Ananda, Hui-Li Wong, Peter Gibbs

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY | WILEY | Published : 2019

Abstract

BACKGROUND: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. RC were defined as tumors proximal to the splenic flexure; LC were those at and distal to the splenic flexure and included rectal cancers. Patient, tumor, treatment, and survival data were analyzed stratified by side. RESULTS: Of 2306 patients enrolled from July 2009-March 2018, 747 (32%) had an RC. Patients with RC were older, mor..

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