Journal article
Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival
S Mendis, S Beck, B Lee, M Lee, R Wong, S Kosmider, J Shapiro, D Yip, S Steel, L Nott, R Jennens, L Lipton, M Burge, K Field, S Ananda, HL Wong, P Gibbs
Asia Pacific Journal of Clinical Oncology | WILEY | Published : 2019
DOI: 10.1111/ajco.13135
Abstract
Background: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. Methods: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. RC were defined as tumors proximal to the splenic flexure; LC were those at and distal to the splenic flexure and included rectal cancers. Patient, tumor, treatment, and survival data were analyzed stratified by side. Results: Of 2306 patients enrolled from July 2009–March 2018, 747 (32%) had an RC. Patients with RC were older, mor..
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