Journal article
Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: A randomized controlled trial
J Freitag, D Bates, J Wickham, K Shah, L Huguenin, A Tenen, K Paterson, R Boyd
Regenerative Medicine | FUTURE MEDICINE LTD | Published : 2019
Abstract
Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell (ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods: 30 participants with symptomatic knee osteoarthritis were randomized into three groups. Two treatment groups received intra-articular ADMSC therapy consisting of either a single injection (100 × 10 6 ADMSCs) or two injections (100 × 10 6 ADMSCs at baseline and 6 months). The third group served as control and continued conservative management. Results: No serious adverse events were observed. Both treatment groups receiving ADMSCs showed clinically significant pain and functional improvement at completion of follow-up at ..
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Funding Acknowledgements
This proposed study was funded jointly by both Magellan Stem Cells and Melbourne Stem Cell Centre. Members of their Medical and Scientific Advisory board have been involved in the study conception and design and are listed as co-authors of this paper. The authors received no payment for their involvement in the study. Interpretation of results, and subsequent submission and publication decisions have been made independent of the sponsors.