Journal article
A controlled human infection model of group A Streptococcus pharyngitis: Which strain and why?
J Osowicki, KI Azzopardi, L McIntyre, T Rivera-Hernandez, CY Ong, C Baker, CM Gillen, MJ Walker, PR Smeesters, MR Davies, AC Steer
Msphere | AMER SOC MICROBIOLOGY | Published : 2019
Abstract
Group A Streptococcus (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Multifaceted characterization studies were done to compare a preferred candidate emm75 (M75) GAS strain to three other strains: an alternative candidate emm12 (M12) strain, an M1 strain used in 1970s pharyngitis CHIM studies (SS-496), and a representative (5448) of the globally disseminated M1T1 clone. A range of approaches were used to explore strain growth..
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Awarded by University of Tennessee
Funding Acknowledgements
J.O. and A.S. are members of the Human Infection Challenge Network for Vaccine Development (HIC-Vac), which is funded by the UK Global Challenges Research Fund (GCRF) Networks in Vaccines Research and Development, which was cofunded by the Medical Research Council (MRC) and Biotechnology and Biological Sciences Research Council (BBSRC). This work was supported by the Australian National Health and Medical Research Council (GNT1099183 and GNT1133299 to J.O.; GNT1126805 to M.R.D.; GNT1102621, GNT1071659, and GNT1074899 to M.J.W.; and GNT1127077 to A.S.), the Australian Heart Foundation (to A. S.), the Garnett Passe and Rodney Williams Memorial Foundation (to C.L.Y.O.), and the Belgian National Fund for Scientific Research (FNRS) (PDR T.0255.16 and CDR J. 0019.17 to P.R.S.).