Journal article

Understanding and exploiting cell signalling convergence nodes and pathway cross-talk in malignant brain cancer

Nok Him Fung, Corrina A Grima, Samuel S Widodo, Andrew H Kaye, Clarissa A Whitehead, Stanley S Stylli, Theo Mantamadiotis

CELLULAR SIGNALLING | ELSEVIER SCIENCE INC | Published : 2019

Abstract

In cancer, complex intracellular and intercellular signals constantly evolve for the advantage of the tumour cells but to the disadvantage of the whole organism. Decades of intensive research have revealed the critical roles of cellular signalling pathways in regulating complex cell behaviours which influence tumour development, growth and therapeutic response, and ultimately patient outcome. Most studies have focussed on specific pathways and the resulting tumour cell function in a rather linear fashion, partly due to the available methodologies and partly due to the traditionally reductionist approach to research. Advances in cancer research, including genomic technologies have led to a de..

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