Understanding and exploiting cell signalling convergence nodes and pathway cross-talk in malignant brain cancer
Nok Him Fung, Corrina A Grima, Samuel S Widodo, Andrew H Kaye, Clarissa A Whitehead, Stanley S Stylli, Theo Mantamadiotis
CELLULAR SIGNALLING | ELSEVIER SCIENCE INC | Published : 2019
In cancer, complex intracellular and intercellular signals constantly evolve for the advantage of the tumour cells but to the disadvantage of the whole organism. Decades of intensive research have revealed the critical roles of cellular signalling pathways in regulating complex cell behaviours which influence tumour development, growth and therapeutic response, and ultimately patient outcome. Most studies have focussed on specific pathways and the resulting tumour cell function in a rather linear fashion, partly due to the available methodologies and partly due to the traditionally reductionist approach to research. Advances in cancer research, including genomic technologies have led to a de..View full abstract
Our laboratories are supported by grants from the CASS Foundation Australia, The Brain Foundation Australia and the Royal Melbourne Hospital Neuroscience Foundation.