Journal article

Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia

Aidan J Kashyap, Kelly J Crossley, Philip LJ DeKoninck, Karyn A Rodgers, Marta Thio, Sasha M Skinner, Jan A Deprest, Stuart B Hooper, Ryan J Hodges

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVE: Infants with a congenital diaphragmatic hernia (CDH) are at high risk of developing pulmonary hypertension after birth, but little is known of their physiological transition at birth. We aimed to characterise the changes in cardiopulmonary physiology during the neonatal transition in an ovine model of CDH. METHODS: A diaphragmatic hernia (DH) was surgically created at 80 days of gestational age (dGA) in 10 fetuses, whereas controls underwent sham surgery (n=6). At 138 dGA, lambs were delivered via caesarean section and ventilated for 2 hours. Physiological and ventilation parameters were continuously recorded, and arterial blood gas values were measured. RESULTS: DH lambs had lowe..

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