Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia
Aidan J Kashyap, Kelly J Crossley, Philip LJ DeKoninck, Karyn A Rodgers, Marta Thio, Sasha M Skinner, Jan A Deprest, Stuart B Hooper, Ryan J Hodges
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | BMJ PUBLISHING GROUP | Published : 2019
OBJECTIVE: Infants with a congenital diaphragmatic hernia (CDH) are at high risk of developing pulmonary hypertension after birth, but little is known of their physiological transition at birth. We aimed to characterise the changes in cardiopulmonary physiology during the neonatal transition in an ovine model of CDH. METHODS: A diaphragmatic hernia (DH) was surgically created at 80 days of gestational age (dGA) in 10 fetuses, whereas controls underwent sham surgery (n=6). At 138 dGA, lambs were delivered via caesarean section and ventilated for 2 hours. Physiological and ventilation parameters were continuously recorded, and arterial blood gas values were measured. RESULTS: DH lambs had lowe..View full abstract
This research project was funded by grants from the Royal Australian and New Zealand College of Obstetricians and Gynaecologists Foundation, Cabrini Foundation, CDH Australia, and the Victorian Government's Operational Infrastructure Support Program.