Journal article

Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials

Paul J Young, Rinaldo Bellomo, Gordon R Bernard, Daniel J Niven, Frederique Schortgen, Manoj Saxena, Richard Beasley, Mark Weatherall

INTENSIVE CARE MEDICINE | SPRINGER | Published : 2019

Abstract

PURPOSE: One potential way to protect patients from the physiological demands that are a consequence of fever is to aim to prevent fever and to treat it assiduously when it occurs. Our primary hypothesis was that more active fever management would increase survival among patient subgroups with limited physiological reserves such as older patients, patients with higher illness acuity, and those requiring organ support. METHODS: We conducted an individual-level patient data meta-analysis of randomised controlled trials to compare the outcomes of ICU patients who received more active fever management with the outcomes of patients who received less active fever management. The primary outcome va..

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University of Melbourne Researchers

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Funding Acknowledgements

This research was conducted during the tenure of a Clinical Practitioner Research Fellowship from the Health Research Council of New Zealand held by PY. The Medical Research Institute of New Zealand is supported by independent research organisation funding from the Health Research Council of New Zealand.