Respiratory sympathetic modulation is augmented in chronic kidney disease

M Saha; C Menuet; QJ Sun; PGR Burke; CM Hildreth; AM Allen; JK Phillips

Journal article

Respiratory sympathetic modulation is augmented in chronic kidney disease

M Saha, C Menuet, QJ Sun, PGR Burke, CM Hildreth, AM Allen, JK Phillips

Respiratory Physiology and Neurobiology | ELSEVIER SCIENCE BV | Published : 2019

DOI: 10.1016/j.resp.2019.02.001

Abstract

Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions (n = 8–10/strain), respiratory modulation of splanchnic and renal nerve activity was compared under control conditions, and during peripheral (hypoxia), and central, chemoreceptor (hypercapnia) challenge. RespSNA was increased in the LPK vs. Lewis (area under curve (AUC) splanchnic and renal: 8.7 ± 1.1 vs. 3.5 ± 0.5 and 10.6 ± 1.1 vs. 7.1 ± 0.2 μV.s, respectively, P < 0.05). Hypoxia and hypercapnia increased respSNA in both strains but the m..

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University of Melbourne Researchers

Andrew Allen Author

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Grants

Awarded by University of Melbourne

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (GNT1030301, GNT1030297, GNT1102477) and Macquarie University Australia. M Saha is a recipient of a Macquarie University International Research Scholarship, and M Menuet was supported by a McKenzie Research Fellowship from the University of Melbourne, Australia.