Multicomponent non-pharmacological intervention to prevent delirium for hospitalised people with advanced cancer: study protocol for a phase II cluster randomised controlled trial
Annmarie Hosie, Jane Phillips, Lawrence Lam, Slavica Kochovska, Beverly Noble, Meg Brassil, Susan E Kurrle, Anne Cumming, Gideon A Caplan, Richard Chye, Brian Le, E Wesley Ely, Peter G Lawlor, Shirley H Bush, Jan Maree Davis, Melanie Lovell, Linda Brown, Belinda Fazekas, Seong Leang Cheah, Layla Edwards Show all
BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2019
INTRODUCTION: Delirium is a significant medical complication for hospitalised patients. Up to one-third of delirium episodes are preventable in older inpatients through non-pharmacological strategies that support essential human needs, such as physical and cognitive activity, sleep, hydration, vision and hearing. We hypothesised that a multicomponent intervention similarly may decrease delirium incidence, and/or its duration and severity, in inpatients with advanced cancer. Prior to a phase III trial, we aimed to determine if a multicomponent non-pharmacological delirium prevention intervention is feasible and acceptable for this specific inpatient group. METHODS AND ANALYSIS: The study is a..View full abstract
Awarded by Australian National Breast Cancer Foundation (NBCF) 2017 Pilot Study Grant
This work was supported by an Australian National Breast Cancer Foundation (NBCF) 2017 Pilot Study Grant (grant code PS-17-030). The trial sponsor is PaCCSC. PaCCSC supports optimal trial governance through SOPs for electronic data handling, completion of CRFs, monitoring, dissemination, archiving of research materials and record destruction; and trial infrastructure through Trials Management and Scientific Committees.