Sex-specific associations between insulin resistance and bone parameters in overweight and obese older adults
Jakub Mesinovic, Lachlan B McMillan, Catherine Shore-Lorenti, Ayse Zengin, Barbora De Courten, Peter R Ebeling, David Scott
CLINICAL ENDOCRINOLOGY | WILEY | Published : 2019
OBJECTIVES: To determine sex-specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography in overweight and obese community-dwelling older adults. STUDY DESIGN: Cross-sectional study of 79 community-dwelling overweight and obese adults (mean ± SD age 62.8 ± 7.9 years; body mass index 32.3 ± 6.1 kg/m2 ; 58% women). MAIN OUTCOME MEASURES: Peripheral quantitative computed tomography assessed distal radius and tibia trabecular volumetric bone mineral density (vBMD) and proximal radius and tibia cortical vBMD, periosteal circumference, endosteal circumference and stress-strain index. The Homeostatic Model Assessment of Insulin Resist..View full abstract
Awarded by National Heart Foundation Future Leader Fellowship
This study was supported by an Australian Institute for Musculoskeletal Science (AIMSS) Seed Grant and University of Melbourne Early Career Researcher Grant. DS is supported by a NHMRC RD Wright Biomedical Career Development Fellowship. JM and LBM are supported by a Research Training Program Scholarship. BdC is supported by a National Heart Foundation Future Leader Fellowship (100864). We gratefully acknowledge the study participants and students and clinicians who contributed to the study.