Modulation of Immunity by Lymphatic Dysfunction in Lymphedema
Yinan Yuan, Valeria Arcucci, Sidney M Levy, Marc G Achen
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2019
The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treatment of cancer. These therapies can damage lymphatic vessels leading to edema, fibrosis, inflammation and dysregulated adipogenesis, which result in profound swelling of an affected limb. Importantly, lymphedema patients often exhibit impaired immune function which predisposes them to a variety of infections. It is known that lymphadenectomy can compromise the acquisition of adaptive immune responses and antibody production; however the cellular mechanisms involved are poorly understood. Here we discuss recent progress in revealing the cellular and molecular mecha..View full abstract
This work was supported by a Program Grant from the National Health and Medical Research Council of Australia, and the Operational Infrastructure Program of the Victorian Government.