Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Ziv Erlich; Inbar Shlomovitz; Liat Edry-Botzer; Hadar Cohen; Daniel Frank; Hanging Wang; Andrew M Lew; Kate E Lawlor; Yifan Zhan; James E Vince; Motti Gerlic

Journal article

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Ziv Erlich, Inbar Shlomovitz, Liat Edry-Botzer, Hadar Cohen, Daniel Frank, Hanging Wang, Andrew M Lew, Kate E Lawlor, Yifan Zhan, James E Vince, Motti Gerlic

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41590-019-0313-5

University of Melbourne Researchers

Yifan Zhan Author Medical Biology (W.E.H.I.)

Kate Lawlor Author Medical Biology (W.E.H.I.)

James Vince Author Medical Biology (W.E.H.I.)

Andrew Lew Author Medical Biology (W.E.H.I.)

Grants

Awarded by Israel Science Foundation (ISF)

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This work was performed in partial fulfillment of the requirements for a Ph.D. degree (for Z.E. and I.S.), the Sackler Faculty of Medicine, Tel Aviv University, Israel. The research of M.G. was supported by the Israel Science Foundation (ISF) (grants 1416/15 and 818/18), alpha-1 Foundation, Recanati Foundation (Tel Aviv University) and individual research grants from the Varda and Boaz Dotan Research Center. The research of Y.Z. and A. M. L. was supported by the National Health and Medical Research Council (NHMRC) of Australia (grants 1037321, 1105209, 1080321 and 1143976). This work was also made possible by NHMRC project grants 1101405 (J.E.V.) and 1145788 (J.E.V. and K. E.L.) and NHMRC Fellowship 1141466 (J.E.V.).