Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
Amy L Burns, Madeline G Dans, Juan M Balbin, Tania F de Koning-Ward, Paul R Gilson, James G Beeson, Michelle J Boyle, Danny W Wilson
FEMS Microbiology Reviews | OXFORD UNIV PRESS | Published : 2019
Plasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resistant to artemisinin combination therapies in Southeast Asia, there is a growing need to develop new antimalarials with novel targets. Invasion of the red blood cell by Plasmodium merozoites is essential for parasite survival and proliferation, thus representing an attractive target for therapeutic development. Red blood cell invasion requires a co-ordinated series of protein/protein interactions, protease cleavage events, intracellular signals, organelle release and engagement of an actin-myosin motor, which provide many potential targets for drug development. As ..View full abstract
Awarded by NHMRC
DW received funding from the NHMRC (Fellowship APP1035715, Project Grant APP1143974) and University of Adelaide Beacon Fellowship. MJB received funding from NHMRC (Career Development Fellowship APP1141632 and Project Grant APP112656), and JGB (1077636) and TdKW (1136300) were supported by NHMRC Senior Research Fellowships. ALB, MGD and JMB recieved support from ARC postgraduate scholarships.