Journal article

The Subplate: A Potential Driver of Cortical Folding?

Shreya Rana, Rosita Shishegar, Sebastian Quezada, Leigh Johnston, David W Walker, Mary Tolcos

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2019


In many species of Mammalia, the surface of the brain develops from a smooth structure to one with many fissures and folds, allowing for vast expansion of the surface area of the cortex. The importance of understanding what drives cortical folding extends beyond mere curiosity, as conditions such as preterm birth, intrauterine growth restriction, and fetal alcohol syndrome are associated with impaired folding in the infant and child. Despite being a key feature of brain development, the mechanisms driving cortical folding remain largely unknown. In this review we discuss the possible role of the subplate, a developmentally transient compartment, in directing region-dependent development lead..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Funding Acknowledgements

S.R. is supported by an Australian Government Research Training Program (RTP) Scholarship. M.T. is an RMIT University Vice Chancellor's Senior Research Fellow and an Australian Research Council Future Fellow (FT180100082). D.W.W. is Program Leader of the Neurodevelopment in Health & Disease [NDHD] Research Program at the School of Health and Biomedical Sciences at RMIT University. This work is partly funded by a National Health and Medical Research Council of Australia grant (APP1061291) to D.W.W., L.J., and M.T., by a grant-in-aid to D.W.W. from RMIT University, and by the Victorian Government's Operational Infrastructure Support fund, who we thank for financial support.