Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino; TS Weber; A Serrano; F Vaillant; K Liu; B Pal; L Di Stefano; J Schreuder; D Lin; Y Chen; ML Asselin-Labat; TN Schumacher; D Cameron; GK Smyth; AT Papenfuss; GJ Lindeman; JE Visvader; SH Naik

Journal article

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

Nature Communications | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41467-019-08595-2

University of Melbourne Researchers

Delphine Merino Author Medical Biology (W.E.H.I.)

Marie-Liesse Asselin-Labat Author Medical Biology (W.E.H.I.)

Francois Vaillant Author Medical Biology (W.E.H.I.)

Tony Papenfuss Author Medical Biology (W.E.H.I.)

Jane Visvader Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council, Australia (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

We are grateful to M. Dawson for critical appraisal, D. Zalcenstein, J. Tran, and M. Ritchie for assistance, S. Wilcox and D. McCarthy for advice, the Royal Melbourne Hospital Tissue Bank, the Victorian Cancer Biobank, and the WEHI Animal, FACS and Histology facilities. This work was supported by the National Health and Medical Research Council, Australia (NHMRC, 1016701, 1040978, 1086727, 1124812, 1062820, 1145814, 1101378, and 1054618); NHMRC IRIISS; the Australian Cancer Research Foundation; The Joan Marshall Breast Cancer Research Fund. D.M. was supported by a NBCF Early Career Fellowship; M.L.A.L. by a Viertel Senior Medical Researcher Fellowship; G.K.S. by NHMRC Research Fellowship 1058892, A.T.P. by NHMRC Research Fellowship (1116955); G.J.L. by NHMRC Research Fellowship (1078730); J.E.V. by NHMRC Fellowships (1037230, 1102742).