The early proximal alpha beta TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Steven C Neier; Alejandro Ferrer; Katelynn M Wilton; Stephen EP Smith; April MH Kelcher; Kevin D Pavelko; Jenna M Canfield; Tessa R Davis; Robert J Stiles; Zhenjun Chen; James McCluskey; Scott R Burrows; Jamie Rossjohn; Deanne M Hebrink; Eva M Carmona; Andrew H Limper; Dietmar J Kappes; Peter J Wettstein; Aaron J Johnson; Larry R Pease; Mark A Daniels; Claudia Neuhauser; Diana Gil; Adam G Schrum

Journal article

The early proximal alpha beta TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Steven C Neier, Alejandro Ferrer, Katelynn M Wilton, Stephen EP Smith, April MH Kelcher, Kevin D Pavelko, Jenna M Canfield, Tessa R Davis, Robert J Stiles, Zhenjun Chen, James McCluskey, Scott R Burrows, Jamie Rossjohn, Deanne M Hebrink, Eva M Carmona, Andrew H Limper, Dietmar J Kappes, Peter J Wettstein, Aaron J Johnson, Larry R Pease Show all

Science Immunology | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019

DOI: 10.1126/sciimmunol.aal2201

University of Melbourne Researchers

James McCluskey Author

Jamie Rossjohn Author Microbiology and Immunology

Zhenjun Chen Author Microbiology and Immunology

Grants

Awarded by NIH

Funding Acknowledgements

This work was supported by the University of Missouri-Columbia and the Mayo Foundation (to D.G. and A.G.S.); NIH grants R01GM103841 (to A.G.S.), R01AI097187 (to D.G.), and R21NS094765 (to A.J.J.); BD Biosciences Research Award (to A.G.S.); NIH training grants T32AI7425 and T32AI007386 (to S.C.N.) and T32GM65841 (to K.M.W.); Consortium of Multiple Sclerosis Centers Foundation Student Research Scholarship Program (to K.M.W.); and the generous philanthropic partnership of B. Fineman with the Mayo Clinic (to A.G.S.).