Journal article
A randomized trial of rTMS targeted with MRI based neuro-navigation in treatment-resistant depression
PB Fitzgerald, K Hoy, S McQueen, JJ Maller, S Herring, R Segrave, M Bailey, G Been, J Kulkarni, ZJ Daskalakis
Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2009
DOI: 10.1038/npp.2008.233
Abstract
The aim of this study is to investigate whether repetitive transcranial magnetic stimulation (rTMS) targeted to a specific site in the dorsolateral prefrontal cortex (DLPFC), with a neuro-navigational method based on structural MRI, would be more effective than rTMS applied using the standard localization technique. Fifty-one patients with treatment-resistant depression were randomized to receive a 3-week course (with a potential 1-week extension) of high-frequency (10 Hz) left-sided rTMS. Thirty trains (5 s duration) were applied daily 5 days per week at 100% of the resting motor threshold. Treatment was targeted with either the standard 5 cm technique (n=27) or using a neuro-navigational a..
View full abstractGrants
Awarded by National Alliance for Research on Schizophrenia and Depression
Funding Acknowledgements
PBF was supported by a Practitioner Fellowship grant from National Health and Medical Research Council (NHMRC) and PBF and ZJD by NARSAD Young Investigator awards. This study was supported in part by a NHMRC project Grant (436710) and the Neurosciences Australia Clinical Neurobiology of Psychiatry Platform. We would like to thank the patients whose participation was essential in the successful completion of this study. The Clinicaltrials. gov trial registration number is NCT00168376 (http://clinicaltrials. gov/ct/show/NCT00168376? order = 1).