Journal article

Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register

Louise J Maple-Brown, Greta Lindenmayer, Federica Barzi, Cherie Whitbread, Christine Connors, Elizabeth Moore, Jacqueline Boyle, Marie Kirkwood, I-Lynn Lee, Danielle Longmore, Paula van Dokkum, Mary Wicks, Michelle Dowden, Chrissie Inglis, Margaret Cotter, Renae Kirkham, Sumaria Corpus, Sridhar Chitturi, Sujatha Thomas, Kerin O'Dea Show all

Journal of Diabetes | WILEY | Published : 2019

Abstract

BACKGROUND: In Australia's Northern Territory, Indigenous mothers account for 33% of births and have high rates of hyperglycemia in pregnancy. The prevalence of type 2 diabetes (T2D) in pregnancy is up to 10-fold higher in Indigenous than non-Indigenous Australian mothers, and the use of metformin is common. We assessed birth outcomes in relation to metformin use during pregnancy from a clinical register. METHODS: The study included women with gestational diabetes (GDM), newly diagnosed diabetes in pregnancy (DIP), or pre-existing T2D from 2012 to 2016. Data were analyzed for metformin use in the third trimester. Regression models were adjusted for maternal age, body mass index, parity, and ..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Program


Awarded by Global Alliance Chronic Disease NHMRC


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

The Northern Territory Diabetes in Pregnancy Partnership is funded by an Australian National Health and Medical Research Council (NHMRC) Partnership Project Grant (1032116), with additional support from NHMRC Program Grant 631974 and Global Alliance Chronic Disease NHMRC Grant 1092968. LM-B is supported by an NHMRC Practitioner Fellowship (1078477). The views expressed in this publication are those of the authors and do not reflect the views of the NHMRC. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.