Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography
Christian Zanchin, Kyohei Yamaji, Carolin Rogge, Dorothea Lesche, Thomas Zanchin, Yasushi Ueki, Stephan Windecker, Paul Mohacsi, Lorenz Raber, Vilborg Sigurdardottir
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
BACKGROUND: The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). METHODS: CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic follow-up (8.5±3.7 years) after heart transplantation. The change in minimal lumen diameter (MLD) and percent diameter stenosis (%DS) was serially assessed within matched segments. Patients were graded according to the ISHLT-CAV classification and grouped as ISHLT-CAV0 and ISHLT-CAV1-3. The primary endpoint was mean change in MLD and %DS. RESULTS: A total of 41 patients and 520 ..View full abstract
Awarded by Swiss National Science Foundation
TZ is funded by an MD-PhD Grant from the Swiss National Science Foundation (grant no. 323530_171146). The study was supported by research grants from Bern University Hospital. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.