Journal article

Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography

Christian Zanchin, Kyohei Yamaji, Carolin Rogge, Dorothea Lesche, Thomas Zanchin, Yasushi Ueki, Stephan Windecker, Paul Mohacsi, Lorenz Raber, Vilborg Sigurdardottir

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018

Abstract

BACKGROUND: The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). METHODS: CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic follow-up (8.5±3.7 years) after heart transplantation. The change in minimal lumen diameter (MLD) and percent diameter stenosis (%DS) was serially assessed within matched segments. Patients were graded according to the ISHLT-CAV classification and grouped as ISHLT-CAV0 and ISHLT-CAV1-3. The primary endpoint was mean change in MLD and %DS. RESULTS: A total of 41 patients and 520 ..

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