c-Maf-dependent T-reg cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis

Christian Neumann; Jonas Blume; Urmi Roy; Peggy P Teh; Ajithkumar Vasanthakumar; Alexander Beller; Yang Liao; Frederik Heinrich; Teresita L Arenzana; Jason A Hackney; Celine Eidenschenk; Eric JC Galvez; Christina Stehle; Gitta A Heinz; Patrick Maschmeyer; Tom Sidwell; Yifang Hu; Derk Amsen; Chiara Romagnani; Hyun-Dong Chang; Andrey Kruglov; Mir-Farzin Mashreghi; Wei Shi; Till Strowig; Sascha Rutz; Axel Kallies; Alexander Scheffold

Journal article

c-Maf-dependent T-reg cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis

Christian Neumann, Jonas Blume, Urmi Roy, Peggy P Teh, Ajithkumar Vasanthakumar, Alexander Beller, Yang Liao, Frederik Heinrich, Teresita L Arenzana, Jason A Hackney, Celine Eidenschenk, Eric JC Galvez, Christina Stehle, Gitta A Heinz, Patrick Maschmeyer, Tom Sidwell, Yifang Hu, Derk Amsen, Chiara Romagnani, Hyun-Dong Chang Show all

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41590-019-0316-2

University of Melbourne Researchers

Yang Liao Author Medical Biology (W.E.H.I.)

Ajith Vasanthakumar Author Microbiology and Immunology

Jonas Blume Author Microbiology and Immunology

Axel Kallies Author Microbiology and Immunology

Wei Shi Author Medical Biology (W.E.H.I.)

Grants

Awarded by Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence Strategy-EXC

Awarded by German Federal Ministry of Education and Science (BMBF)-Project InfectControl 2020 Projekt DIAT

Awarded by 'European Regional Development Fund' ERDF 2014-2020

Awarded by Helmholtz Association

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This research was supported by the Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence Strategy-EXC 2167-390884018 (to A.S.), SFB650 (to A.S.) and CRC/TR 241 (to A.S. and C.R.), the German Federal Ministry of Education and Science (BMBF)-Project InfectControl 2020 Projekt DIAT FKZ: 03ZZ0827A (to A.S.), the state of Berlin and the 'European Regional Development Fund' ERDF 2014-2020, EFRE 1.8/11, Deutsches Rheuma-Forschungszentrum (to F.H., G.A.H, P.M. and M.F.M), the Helmholtz Association project grant VH-NG-933 (to T. Strowig), the National Health and Medical Research Council (NHMRC) project grants (1069075, 1106378 to A. Kallies), the Sylvia and Charles Viertel Foundation (fellowship to A. Kallies), a Walter and Eliza Institute Centenary Fellowship funded by the CSL (to W.S.), a fellowship by the Deutsche Forschungsgemeinschaft (to J.B.) and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme. We thank the DRFZ Flow Cytometry Core Facility and the BCRT Flow Cytometry Lab for cell sorting. In addition, we thank Renee Gloury and Victoria von Gotze for technical and experimental help.