Journal article

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

Scott Ayton, Yamin Wang, Ibrahima Diouf, Julie A Schneider, John Brockman, Martha Clare Morris, Ashley I Bush

MOLECULAR PSYCHIATRY | SPRINGERNATURE | Published : 2020

Abstract

Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of the directly measured iron on the clinical syndrome has not been assessed. We investigated the association between post-mortem iron levels with the clinical and pathological diagnosis of AD, its severity, and the rate of cognitive decline in the 12 years prior to death in subjects from the Memory and Aging Project (n = 209). Iron was elevated (β [SE] = 9.7 [2.6]; P = 3.0 × 10-4) in the inferior temporal cortex only in subjects who were diagnosed with clinical AD during life and had a diagnosis of AD confirmed post-mortem by standardized criteria. Although iron was weakly associated with the extent of p..

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