Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes

Taylor M Triolo; Alexandra Fouts; Laura Pyle; Liping Yu; Peter A Gottlieb; Andrea K Steck; CJ Greenbaum; M Atkinson; D Baidal; M Battaglia; D Becker; P Bingley; E Bosi; J Buckner; M Clements; P Colman; L DiMeglio; S Gitelman; R Goland; P Gottlieb; K Herold; M Knip; J Krischer; A Lernmark; W Moore; A Moran; A Muir; J Palmer; M Peakman; L Philipson; P Raskin; M Redondo; H Rodriguez; W Russell; L Spain; DA Schatz; J Sosenko; J Wentworth; D Wherrett; D Wilson; W Winter; A Ziegler; M Anderson; P Antinozzi; C Benoist; J Blum; K Bourcier; P Chase; M Clare-Salzler; R Clynes; G Eisenbarth; CG Fathman; G Grave; B Hering; R Insel; F Kaufman; T Kay; E Leschek; J Mahon; JB Marks; K Nanto-Salonen; G Nepom; T Orban; R Parkman; M Pescovitz; J Peyman; A Pugliese; B Roep; M Roncarolo; P Savage; O Simell; R Sherwin; M Siegelman; JS Skyler; A Steck; J Thomas; M Trucco; J Wagner; JP Krischer; L Rafkin; C Cowie; M Foulkes; H Krause-Steinrauf; JM Lachin; S Malozowski; J Peyman; J Ridge; P Savage; SJ Zafonte; JM Sosenko; NS Kenyon; I Santiago; B Bundy; M Abbondondolo; T Adams; D Amado; I Asif; M Boonstra; C Burroughs; D Cuthbertson; M Deemer; C Eberhard; S Fiske; J Ford; J Garmeson; H Guillette; S Geyer; B Hays; C Henderson; M Henry; K Heyman; B Hsiao; C Karges; N Keaton; A Kinderman; P Law; A Leinbach; S Liu; J Lloyd; J Malloy; K Maddox; J Martin; J Miller; E Milliot; M Moore; S Muller; T Nguyen; R O'Donnell; A Roberts; K Sadler; T Stavros; R Tamura; K Wood; P Xu; K Young; P Alies; F Badias; A Baker; M Bassi; C Beam; D Boulware; L Bounmananh; S Bream; D Freeman; J Gough; J Ginem; M Granger; MH Michelle Kieffer; P Lane; C Linton; L Nallamshetty; V Oduah; Y Parrimon; K Paulus; J Pilger; J Ramiro; A Luvon Ritzie; A Sharma; A Shor; X Song; A Terry; J Weinberger; M Wootten; JM Lachin; P Harding; H Krause-Steinrauf; S McDonough; PF McGee; K Owens Hess; D Phoebus; S Quinlan; E Raiden; E Batts; C Buddy; K Kirpatrick; M Ramey; A Shultz; C Webb; M Romesco; J Fradkin; P Savage; S Aas; E Blumberg; G Beck; D Brillon; R Gubitosi-Klug; L Laffel; R Vigersky; D Wallace; J Braun; B Lo; H Mitchell; A Naji; J Nerup; T Orchard; M Steffes; A Tsiatis; R Veatch; B Zinman; B Loechelt; L Baden; M Green; A Weinberg; S Marcovina; JP Palmer; S Babu; J Marks; D Matheson; D Gomez; A McDonald; S Pena; M Pietropaolo; K Shippy; T Brown; A Dove; M Hammond; D Hefty; J Klein; K Kuhns; M Letlau; S Lord; M McCulloch-Olson; L Miller; J Odegard; E Sachter; M St Marie; K Stickney; D VanBuecken; B Vellek; C Webber; L Allen; J Bollyk; N Hilderman; H Ismail; S Lamola; S Sanda; H Vendettuoli; D Tridgell; R Monzavi; M Bock; L Fisher; M Halvorson; D Jeandron; M Kim; J Wood; M Geffner; R Parkman; C Salazar; S Cook; M Freeby; Pat M Gallagher; R Gandica; E Greenberg; A Kurland; S Pollak; A Wolk; M Chan; L Koplimae; E Levine; K Smith; J Trast; C Evans-Molina; R Hufferd; B Jagielo; C Kruse; V Patrick; M Rigby; M Spall; K Swinney; J Terrell; L Christner; L Ford; S Lynch; M Menendez; P Merrill; C Alleyn; D Baidal; S Fay; J Gaglia; B Resnick; S Szubowicz; G Weir; R Benjamin; D Conboy; A deManbey; R Jackson; H Jalahej; A Ricker; J Wolfsdorf; HH Zhang; T Aye; B Baker; K Barahona; B Buckingham; K Esrey; T Esrey; G Fathman; R Snyder; B Aneja; M Chatav; O Espinoza; E Frank; J Liu; J Perry; R Pyle; A Rigby; K Riley; A Soto; S Adi; A Berhel; K Breen; K Fraser; A Gerard-Gonzalez; P Jossan; R Lustig; S Moassesfar; A Mugg; D Ng; P Prahalod; M Rangel-Lugo; J Tarkoff; C Torok; R Wesch; I Aslan; J Buchanan; J Cordier; C Hamilton; L Hawkins; T Ho; A Jain; K Ko; T Lee; S Phelps; S Rosenthal; T Sahakitrungruang; L Stehl; L Taylor; M Wertz; J Wong; R Briars; N Devine; E Littlejohn; T Grant; G Klingensmith; A Alkanani; K Bautista; R Bedoy; A Blau; B Burke; L Cory; M Dang; L Fitzgerald-Miller; A Fouts; V Gage; S Garg; P Gesauldo; R Gutin; C Hayes; M Hoffman; K Ketchum; N Logsden-Sackett; D Maahs; L Messer; L Meyers; A Michels; S Peacock; M Rewers; P Rodriguez; F Sepulbeda; R Sippl; A Steck; I Taki; BK Tran; T Tran; RP Wadwa; P Zeitler; J Barker; S Barry; L Birks; L Bomsburger; T Bookert; L Briggs; P Burdick; R Cabrera; P Chase; E Cobry; A Conley; G Cook; J Daniels; D DiDomenico; J Eckert; A Ehler; P Fain; R Fiallo-Scharer; N Frank; H Goettle; M Haarhues; S Harris; L Horton; J Hutton; J Jeffrrey; R Jenison; K Jones; W Kastelic; MA King; D Lehr; J Lungaro; K Mason; H Maurer; L Nguyen; A Proto; J Realsen; K Schmitt; M Schwartz; S Skovgaard; J Smith; B Vanderwel; M Voelmle; R Wagner; A Wallace; P Walravens; L Weiner; B Westerhoff; E Westfall; K Widmer; H Wright; D Schatz; A Abraham; M Atkinson; M Cintron; M Clare-Salzler; J Ferguson; M Haller; J Hosford; D Mancini; H Rohrs; J Silverstein; W Winter; G Cole; R Cook; R Coy; E Hicks; N Lewis; J Marks; A Pugliese; C Blaschke; D Matheson; A Pugliese; N Sanders-Branca; Ray LA Arce; M Cisneros; S Sabbag; A Moran; C Gibson; B Fife; B Hering; C Kwong; J Leschyshyn; B Nathan; B Pappenfus; A Street; MA Boes; Peterson S Eck; L Finney; Albright T Fischer; A Martin; Jacqueline C Muzamhindo; M Rhodes; J Wagner; B Wood; D Becker; K Delallo; A Diaz; B Elnyczky; I Libman; B Pasek; K Riley; M Trucco; B Copemen; D Gwynn; F Toledo; S Bollepalli; F Diamond; E Eyth; D Henson; A Lenz; D Shulman; P Raskin; S Adhikari; B Dickson; E Dunnigan; I Lingvay; L Pruneda; M Ramos-Roman; C Rhee; J Richard; M Siegelman; D Sturges; K Sumpter; P White; M Alford; J Arthur; ML Aviles-Santa; E Cordova; R Davis; S Fernandez; S Fordan; T Hardin; A Jacobs; P Kaloyanova; I Lukacova-Zib; S Mirfakhraee; A Mohan; H Noto; O Smith; N Torres; D Wherrett; D Balmer; L Eisel; R Kovalakovska; M Mehan; F Sultan; B Ahenkorah; J Cevallos; N Razack; Jo M Ricci; A Roode; M Srikandarajah; R Steger; WE Russell; M Black; F Brendle; A Brown; D Moore; E Pittel; A Robertson; A Shannon; JW Thomas; K Herold; L Feldman; R Sherwin; W Tamborlane; S Weinzimer; J Toppari; T Kallio; M Karkkainen; E Mantymaki; T Niininen; B Nurmi; P Rajala; M Romo; S Suomenrinne; K Nanto-Salonen; O Simell; T Simell; E Bosi; M Battaglia; E Bianconi; R Bonfanti; P Grogan; A Laurenzi; S Martinenghi; F Meschi; M Pastore; L Falqui; Teresa M Muscato; M Viscardi; H Castleden; N Farthing; S Loud; C Matthews; J McGhee; A Morgan; J Pollitt; R Elliot-Jones; C Wheaton; M Knip; H Siljander; H Suomalainen; P Colman; F Healy; S Mesfin; L Redl; J Wentworth; J Willis; M Farley; L Harrison; C Perry; F Williams; A Mayo; J Paxton; V Thompson; L Volin; C Fenton; L Carr; E Lemon; M Swank; MK Luidens; M Salgam; V Sharma; D Schade; C King; R Carano; J Heiden; ND Means; L Holman; I Thomas; D Madrigal; T Muth; CL Martin; C Plunkett; C Ramm; RJ Auchus; W Lane; E Avots; M Buford; C Hale; J Hoyle; B Lane; S Shuler; N Raviele; E Ivie; M Jenkins; K Lindsley; I Hansen; DO Fadoju; E Felner; B Bode; R Hosey; J Sax; C Jefferies; S Mannering; R Prentis; JX She; M Stachura; D Hopkins; J Williams; L Steed; E Asatapova; S Nunez; S Knight; P Dixon; J Ching; T Donner; S Longnecker; K Abel; K Arcara; S Blackman; L Clark; D Cooke; L Plotnick; PA Levin; L Bromberger; K Klein; K Sadurska; C Allen; D Michaud; H Snodgrass; G Burghen; S Chatha; C Clark; J Silverberg; C Wittmer; J Gardner; C LeBoeuf; P Bell; O McGlore; H Tennet; N Alba; M Carroll; L Baert; H Beaton; E Cordell; A Haynes; C Reed; K Lichter; P McCarthy; S McCarthy; T Monchamp; J Roach; S Manies; F Gunville; L Marosok; T Nelson; K Ackerman; J Rudolph; M Stewart; K McCormick; S May; T Falls; T Barrett; K Dale; L Makusha; C McTernana; K Penny-Thomas; K Sullivan; P Narendran; J Robbie; D Smith; R Christensen; B Koehler; C Royal; T Arthur; H Houser; J Renaldi; S Watsen; P Wu; L Lyons; B House; J Yu; H Holt; M Nation; C Vickers; R Watling; R Heptulla; C Agarwal; DJ Newell; R Katikaneni; C Gardner; A Del Rio; A Logan; H Collier; C Rishton; G Whalley; A Ali; S Ramtoola; T Quattrin; L Mastrandea; AJ House; M Ecker; C Huang; C Gougeon; J Ho; D Pacuad; D Dunger; J May; C O'Brien; C Acerini; B Salgin; A Thankamony; R Williams; J Buse; G Fuller; M Duclos; J Tricome; H Brown; D Pittard; D Bowlby; A Blue; T Headley; S Bendre; K Lewis; K Sutphin; C Soloranzo; J Puskaric; H Madison; M Rincon; M Carlucci; R Shridharani; B Rusk; E Tessman; DM Huffman; H Abrams; B Biederman; MD Jones; V Leathers; W Brickman; P Petrie; D Zimmerman; J Howard; L Miller; R Alemzadeh; D Mihailescu; R Melgozza-Walker; N Abdulla; C Boucher-Berry; C Ize-Ludlow; R Levy; Brousell C Swenson; R Scott; H Heenan; H Lunt; D Kendall; J Willis; B Darlow; N Crimmins; D Edler; T Weis; C Schultz; D Rogers; D Latham; C Mawhorter; C Switzer; W Spencer; P Konstantnopoulus; S Broder; J Klein; B Bachrach; M Gardner; D Eichelberger; L Knight; L Szadek; G Welnick; B Thompson; R Hoffman; A Revell; J Cherko; K Carter; E Gilson; J Haines; G Arthur; B Bowen; WB Zipf; P Graves; RA Lozano; D Seiple; K Spicer; A Chang; J Fregosi; J Harbinson; C Paulson; S Stalters; P Wright; D Zlock; AE Freeth; J Victory; H Maheshwari; A Maheshwari; T Holmstrom; J Bueno; R Arguello; J Ahern; L Noreika; V Watson; S Hourse; P Breyer; C Kissel; Y Nicholson; M Pfeifer; S Almazan; J Bajaj; M Quinn; K Funk; J McCance; E Moreno; R Veintimilla; S Wells; J Cook; S Trunnel; D Transue; J Surhigh; D Bezzaire; K Moltz; E Zacharski; J Henske; S Desai; K Frizelis; F Khan; R Sjoberg; K Allen; PP Manning; G Hendry; B Taylor; S Jones; R Couch; D Danchak; D Lieberman; W Strader; ME Bencomo; T Bailey; L Bedolla; C Roldan; C Moudiotis; B Vaidya; C Anning; S Bunce; S Estcourt; E Folland; E Gordon; C Harrill; J Ireland; J Piper; L Scaife; K Sutton; S Wilkins; M Costelloe; L Casas; C Miller; M Burgard; J Hallanger-Johnson; P Clark; W Taylor; J Galgani; S Banerjee; C Banda; D McEowen; R Kinman; A Lafferty; S Gillett; C Nolan; M Pathak; L Sondrol; T Hjelle; S Hafner; J Kotrba; R Hendrickson; AP Cemeroglu; T Symington; M Daniel; Y Appiagyei-Dankah; DC Postellon; MS Racine; L Kleis; K Barnes; SE Godwin; H McCullough; K Shaheen; G Buck; L Noel; ML Warren; S Weber; SM Parker; I Gillespie; BA Nelson; C Frost; J Amrhein; EC Moreland; A Hayes; J Peggram; J Aisenberg; ME Riordan; J Zasa; E Cummings; K Scott; T Pinto; A Mokashi; K McAssey; E Helden; P Hammond; L Dinning; S Rahman; S Ray; C Dimicri; S Guppy; H Nielsen; CK Vogel; C Ariza; L Morales; YT Chang; RA Gabbay; L Ambrocio; L Manley; R Nemery; W Charlton; P Smith; L Kerr; B Steindel-Kopp; M Alamaguer; E Tabisola-Nuesca; A Pendersen; N Larson; H Cooper-Olviver; D Chan; D Fitz-Patrick; T Carreira; Y Park; R Ruhaak; D Liljenquist; G Browning; T Coughenour; MB Sulk; E Tsalikan; M Tansey; J Cabbage; N Dixit; S Pasha; M King; K Adcock; H Atterberry; L Fox; K Englert; N Mauras; J Permuy; K Sikes; T Berhe; B Guendling; L McLennan; L Paganessi; C Murphy; MB Draznin; M Kamboj; S Sheppard; V Lewis; L Coates; W Moore; G Babar; J Bedard; D Brenson-Hughes; J Cernich; M Clements; R Duprau; S Goodman; L Hester; L Huerta-Saenz; A Karmazin; T Letjen; S Raman; D Morin; W Bestermann; EJ Morawski; JL White; A Brockmyer; R Bays; S Campbell; A Stapleton; N Stone; A Donoho; H Everett; H Hensley; M Johnson; C Marshall; N Skirvin; P Taylor; L Ray; C Wolverton; DA Nickels; C Dothard; PW Speiser; M Pellizzari; L Bokor; K Izuora; S Abdelnour; P Cummings; S Paynor; M Leahy; M Riedl; S Shockley; R Saad; T Briones; S Casella; C Herz; K Walsh; J Greening; F Hay; S Hunt; N Sikotra; L Simons; DG Karounos; R Oremus; L Dye; L Myers; D Ballard; W Miers; R Sparks; KM Thraikill; K Edwards; J Fowlkes; S Kemp; A Morales; L Holland; L Johnson; P Paul; A Ghatak; K Phelen; H Leyland; T Henderson; D Brenner; E Oppenheimer; I Mamkin; C Moniz; C Clarson; M Lovell; A Peters; V Ruelas; D Borut; D Burt; M Jordan; S Castilla; P Flores; M Ruiz; L Hanson; J Green-Blair; RJ Sheridan; KA Wintergerst; G Pierce; A Omoruyi; M Foster; S Kingery; A Lunsford; I Cervantes; T Parker; P Price; J Urben; I Doughty; H Haydock; V Parker; P Bergman; S Duncum; C Rodda; AD Thomas; R Ferry; D McCommon; J Cockroft; A Perelman; R Calendo; C Barrera; E Arce-Nunez; Y Martinez; M De la Portilla; I Cardenas; L Garrido; M Villar; R Lorini; E Calandra; G D'Annuzio; K Perri; N Minuto; C Rebora; R Callegari; O Ali; J Kramer; B Auble; S Cabrera; P Donohoue; R Fiallo-Scharer; M Hessner; P Wolfgram; A Kansra; N Bettin; R McCuller; A Miller; S Accacha; J Corrigan; E Fiore; RL Levine; TA Mahoney; C Polychronakos; V Gagne; H Starkman; M Fox; D Chin; F Melchionne; LA Silverman; I Marshall; L Cerracchio; J Cruz; A Viswanathan; J Wilson; S Chalew; S Valley; S Layburn; A Lala; P Clesi; M Genet; G Uwaifo; A Charron; T Allerton; W Cefalu; L Melendez-Ramirez; R Richards; C Alleyn; E Gustafson; M Lizanna; J Wahlen; S Aleiwe; M Hansen; H Wahlen; CJ Levy; A Bonaccorso; R Rapaport; Y Tomer; D Chia; M Goldis; L Iazzetti; M Klein; C Levister; L Waldman; E Wallach; MO Regelmann; Z Antal; M Aranda; C Reynholds; N Leech; D Wake; C Owens; M Burns; J Wotherspoon; L Wynn; E Wiltshire; J Krebs; P Cresswell; H Faherty; C Ross; A Vinik; P Barlow; M Bourcier; ML Nevoret; J Couper; S Beresford; N Thalagne; H Roper; J Gibbons; J Hill; S Balleaut; C Brennan; J Ellis-Gage; L Fear; T Gray; L Jones; C McNerney; L Pointer; N Price; 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Journal article

Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes

Taylor M Triolo, Alexandra Fouts, Laura Pyle, Liping Yu, Peter A Gottlieb, Andrea K Steck, CJ Greenbaum, M Atkinson, D Baidal, M Battaglia, D Becker, P Bingley, E Bosi, J Buckner, M Clements, P Colman, L DiMeglio, S Gitelman, R Goland, P Gottlieb Show all

DIABETES CARE | AMER DIABETES ASSOC | Published : 2019

DOI: 10.2337/dc18-0288

Abstract

OBJECTIVE: There are variable reports of risk of concordance for progression to islet autoantibodies and type 1 diabetes in identical twins after one twin is diagnosed. We examined development of positive autoantibodies and type 1 diabetes and the effects of genetic factors and common environment on autoantibody positivity in identical twins, nonidentical twins, and full siblings. RESEARCH DESIGN AND METHODS: Subjects from the TrialNet Pathway to Prevention Study (N = 48,026) were screened from 2004 to 2015 for islet autoantibodies (GAD antibody [GADA], insulinoma-associated antigen 2 [IA-2A], and autoantibodies against insulin [IAA]). Of these subjects, 17,226 (157 identical twins, 283 noni..

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University of Melbourne Researchers

Peter Colman Author

Thomas Kay Author

Peter Colman Author

John Wentworth Author

Grants

Awarded by National Institute of Diabetes and Digestive and Kidney Diseases T32 training fellowship

Awarded by American Diabetes Association

Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development

Funding Acknowledgements

T.M.T. is supported by the National Institute of Diabetes and Digestive and Kidney Diseases T32 training fellowship (5T32-DK-063687-14). A.K.S. is supported by American Diabetes Association grant 1-14-CD-17. The Type 1 Diabetes TrialNet Pathway to Prevention Study Group is a clinical trials network funded by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Allergy and Infectious Diseases, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development through cooperative agreements U01-DK-061010, U01-DK-061034, U01-DK-061042, U01-DK-061058, U01-DK-085465, U01-DK-085453, U01-DK-085461, U01-DK-085463, U01-DK-085466, U01-DK-085499, U01-DK-085504, U01-DK-085505, U01-DK-085509, U01-DK-103180, U01-DK-103153, U01-DK-085476, and U01-DK-103266 and by JDRF International.