Journal article

Palladium-catalyzed decarboxylative cross-coupling reactions: a route for regioselective functionalization of coumarins.

Farnaz Jafarpour, Samaneh Zarei, Mina Barzegar Amiri Olia, Nafiseh Jalalimanesh, Soraya Rahiminejadan

J Org Chem | American Chemical Society (ACS) | Published : 2013


A straightforward, regioselective, and step-economical ligand-free palladium-catalyzed decarboxylative functionalization of coumarin-3-carboxylic acids is devised. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and allows for construction of various biologically important π-electron extended coumarins.

University of Melbourne Researchers