Journal article

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine

Zhiling Li, Marlene M Hao, Chris Van den Haute, Veerle Baekelandt, Werend Boesmans, Pieter Vanden Berghe

eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2019

Abstract

The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes that coordinate the transition between those patterns are poorly understood. We investigated whether in regions with a richer palette of motility patterns, the underlying nerve circuits reflect this complexity. Using Ca2+ imaging, we determined the location and response fingerprint of large populations of enteric neurons upon focal network stimulation. Complemented by neuronal tra..

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University of Melbourne Researchers

Grants

Awarded by Chinese Scholarship Council


Awarded by National Health and Medical Research Council


Awarded by Fonds Wetenschappelijk Onderzoek


Awarded by KU Leuven


Awarded by Hercules Foundation


Awarded by Belgian National Fund for Scientific Research


Awarded by Instituut voor Innovatie door Wetenschap en Technologie


Funding Acknowledgements

Chinese Scholarship Council 201408370078 Zhiling LiNational Health and Medical Research Council APP1655567 Marlene M HaoFonds Wetenschappelijk Onderzoek 12G1214N Marlene M HaoKU Leuven C32/15/031 Veerle BaekelandtFonds Wetenschappelijk Onderzoek SBO/S006617N Veerle BaekelandtFonds Wetenschappelijk Onderzoek G.0921.15 Werend Boesmans Pieter Vanden BergheHercules Foundation AKUL/15/37 Werend Boesmans Pieter Vanden BergheHercules Foundation AKUL/11/37 Pieter Vanden BergheHercules Foundation AKUL/13/37 Pieter Vanden BergheBelgian National Fund for Scientific Research G.0921.15 SBO/S006617N Pieter Vanden BergheInstituut voor Innovatie door Wetenschap en Technologie SBO/130065 Pieter Vanden BergheThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.