Role of PCK1 gene on oil tea-induced glucose homeostasis and type 2 diabetes: An animal experiment and a case-control study

Abstract

Background: Oil tea is a type of traditional tea beverage used for treating various ailments in minority population in Guangxi, China. Our previous study showed oil tea improved glucose and lipid levels in type 2 diabetic mice. Yet, the underling molecular mechanisms are still not understood. This study aimed at assessing the effect of oil tea on glucose homeostasis and elucidating the molecular mechanisms underlying the oil tea-induced antidiabetic effects. Methods: Twenty seven db/db mice were gavaged with saline, metformin and oil tea for 8 weeks with measurement of biochemical profiles. A real-time 2 (RT 2 ) profiler polymerase chain reaction (PCR) array comprising 84 genes involved in g..