Journal article

How pharmacoepidemiology networks can manage distributed analyses to improve replicability and transparency and minimize bias

Robert W Platt, Richard Platt, Jeffrey S Brown, David A Henry, Olaf H Klungel, Samy Suissa

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY | WILEY | Published : 2020

Abstract

Several pharmacoepidemiology networks have been developed over the past decade that use a distributed approach, implementing the same analysis at multiple data sites, to preserve privacy and minimize data sharing. Distributed networks are efficient, by interrogating data on very large populations. The structure of these networks can also be leveraged to improve replicability, increase transparency, and reduce bias. We describe some features of distributed networks using, as examples, the Canadian Network for Observational Drug Effect Studies, the Sentinel System in the USA, and the European Research Network of Pharmacovigilance and Pharmacoepidemiology. Common protocols, analysis plans, and ..

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Grants

Awarded by Canadian Institutes of Health Research


Funding Acknowledgements

Canadian Institutes of Health Research, Grant/Award Number: DSE-146021