Serotonin-Norepinephrine Reuptake Inhibitors and the Risk of AKI: A Cohort Study of Eight Administrative Databases and Meta-Analysis
Christel Renoux, Lisa M Lix, Valerie Patenaude, Lauren C Bresee, J Michael Paterson, Jean-Philippe Lafrance, Hala Tamim, Salaheddin M Mahmud, Mhd Wasem Alsabbagh, Brenda Hemmelgarn, Colin R Dormuth, Pierre Ernst
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMER SOC NEPHROLOGY | Published : 2015
BACKGROUND AND OBJECTIVES: A safety signal regarding cases of AKI after exposure to serotonin-norepinephrine reuptake inhibitors (SNRIs) was identified by Health Canada. Therefore, this study assessed whether the use of SNRIs increases the risk of AKI compared with selective serotonin reuptake inhibitors (SSRIs) and examined the risk associated with each individual SNRI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Multiple retrospective population-based cohort studies were conducted within eight administrative databases from Canada, the United States, and the United Kingdom between January 1997 and March 2010. Within each cohort, a nested case-control analysis was performed to estimate in..View full abstract
Awarded by Canadian Institutes of Health Research
CNODES, a collaborating center of the Drug Safety and Effectiveness Network, is funded by the Canadian Institutes of Health Research (Grant DSE-111845). C.R. has received a Chercheur-Boursier Award from the Quebec Health Research Fund.