Journal article

Cost-effectiveness of different interferon beta products for relapsing-remitting and secondary progressive multiple sclerosis: Decision analysis based on long-term clinical data and switchable treatments

Shekoufeh Nikfar, Abbas Kebriaeezadeh, Rassoul Dinarvand, Mohammad Abdollahi, Mohammad-Ali Sahraian, David Henry, Ali Akbari Sari

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES | BIOMED CENTRAL LTD | Published : 2013

Abstract

BACKGROUND: Multiple sclerosis (MS) is a highly debilitating immune mediated disorder and the second most common cause of neurological disability in young and middle-aged adults. Iran is amongst high MS prevalence countries (50/100,000). Economic burden of MS is a topic of important deliberation in economic evaluations study. Therefore determining of cost-effectiveness interferon beta (INF β) and their copied biopharmaceuticals (CBPs) and biosimilars products is significant issue for assessment of affordability in Lower-middle-income countries (LMICs). METHODS: A literature-based Markov model was developed to assess the cost-effectiveness of three INF βs products compared with placebo for ma..

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Funding Acknowledgements

Authors thank Iranian Society of multiple sclerosis for their kind assistance in collecting information of patients. This paper is the outcome of a PhD thesis of the first author and was supported by Faculty of Pharmacy, Tehran University of Medical Sciences.