Journal article

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Roxanne Hastie, Natasha De Alwis, Ping Cannon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | ELSEVIER SCI LTD | Published : 2019

Abstract

Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and end-organ injury. Adrenomedullin (ADM) is a pro-angiogenic peptide hormone which regulates blood pressure and vascular integrity. It is highly expressed in both the placenta and vascular endothelial cells. We performed a nested case-control study, selected from a large prospective cohort of over 2000 participants. Circulating ADM mRNA was reduced at both 28 (n = 39 vs 248 controls, p = 0.005) and 36 weeks' of pregnancy (n = 39 vs 205 controls, p < 0.0001) in those destined to develop term preeclampsia. It was also significantly reduced in the ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC of Australia)


Awarded by NHMRC Fellowships


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC of Australia (#1065854), Australian Government Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; and the Norman Beischer Medical Research Foundation. S Tong (#1136418), T. J. Kaitu'u-Lino (#1062418) and N. J. Hannan (#1146128) were supported by NHMRC Fellowships. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.