Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia
Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Roxanne Hastie, Natasha De Alwis, Ping Cannon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | ELSEVIER SCI LTD | Published : 2019
Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and end-organ injury. Adrenomedullin (ADM) is a pro-angiogenic peptide hormone which regulates blood pressure and vascular integrity. It is highly expressed in both the placenta and vascular endothelial cells. We performed a nested case-control study, selected from a large prospective cohort of over 2000 participants. Circulating ADM mRNA was reduced at both 28 (n = 39 vs 248 controls, p = 0.005) and 36 weeks' of pregnancy (n = 39 vs 205 controls, p < 0.0001) in those destined to develop term preeclampsia. It was also significantly reduced in the ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC of Australia)
Awarded by NHMRC Fellowships
This work was supported by the National Health and Medical Research Council (NHMRC of Australia (#1065854), Australian Government Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; and the Norman Beischer Medical Research Foundation. S Tong (#1136418), T. J. Kaitu'u-Lino (#1062418) and N. J. Hannan (#1146128) were supported by NHMRC Fellowships. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.