Journal article

Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development

Tuong-Vi Nguyen, Mia Wu, Jimin Lew, Matthew D Albaugh, Kelly N Botteron, James J Hudziak, Vladimir S Fonov, D Louis Collins, Benjamin C Campbell, Linda Booij, Catherine Herba, Patricia Monnier, Simon Ducharme, James T McCracken

PSYCHONEUROENDOCRINOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

Existing studies suggest that dehydroepiandrosterone (DHEA) may be important for human brain development and cognition. For example, molecular studies have hinted at the critical role of DHEA in enhancing brain plasticity. Studies of human brain development also support the notion that DHEA is involved in preserving cortical plasticity. Further, some, though not all, studies show that DHEA administration may lead to improvements in working memory in adults. Yet these findings remain limited by an incomplete understanding of the specific neuroanatomical mechanisms through which DHEA may impact the CNS during development. Here we examined associations between DHEA, cortico-hippocampal structur..

View full abstract

Grants

Awarded by National Institute of Neurological Disorders and Stroke


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

This work was supported by Federal funds from the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke (Contract #s N01-HD02-3343, N01-MH9-0002, and N01-NS-9-2314, -2315, -2316, -2317, -2319 and -2320).