Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function.
Tuong-Vi Nguyen, Jimin Lew, Matthew D Albaugh, Kelly N Botteron, James J Hudziak, Vladimir S Fonov, D Louis Collins, Simon Ducharme, James T McCracken
Psychoneuroendocrinology | Published : 2017
Testosterone is thought to play a crucial role in mediating sexual differentiation of brain structures. Examinations of the cognitive effects of testosterone have also shown beneficial and potentially sex-specific effects on executive function and mnemonic processes. Yet these findings remain limited by an incomplete understanding of the critical timing and brain regions most affected by testosterone, the lack of documented links between testosterone-related structural brain changes and cognition, and the difficulty in distinguishing the effects of testosterone from those of related sex steroids such as of estradiol and dehydroepiandrosterone (DHEA). Here we examined associations between tes..View full abstract
Awarded by NINDS NIH HHS
Awarded by NIMH NIH HHS
Awarded by NICHD NIH HHS