A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL.
Yi Xing, Stefan L Oliver, TuongVi Nguyen, Claudio Ciferri, Avishek Nandi, Julie Hickman, Cinzia Giovani, Edward Yang, Giuseppe Palladino, Charles Grose, Yasushi Uematsu, Anders E Lilja, Ann M Arvin, Andrea Carfí
Proceedings of the National Academy of Sciences of USA | Published : 2015
Varicella-zoster virus (VZV), of the family Alphaherpesvirinae, causes varicella in children and young adults, potentially leading to herpes zoster later in life on reactivation from latency. The conserved herpesvirus glycoprotein gB and the heterodimer gHgL mediate virion envelope fusion with cell membranes during virus entry. Naturally occurring neutralizing antibodies against herpesviruses target these entry proteins. To determine the molecular basis for VZV neutralization, crystal structures of gHgL were determined in complex with fragments of antigen binding (Fabs) from two human monoclonal antibodies, IgG-94 and IgG-RC, isolated from seropositive subjects. These structures reveal that ..View full abstract
Awarded by NIAID NIH HHS