Journal article

Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant Staphylococcus aureus

Sarah L Baines, Slade O Jensen, Neville Firth, Anders Goncalves da Silva, Torsten Seemann, Glen P Carter, Deborah A Williamson, Benjamin P Howden, Timothy P Stinear

Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2019

Abstract

Staphylococcus aureus is a significant human pathogen whose evolution and adaptation have been shaped in part by mobile genetic elements (MGEs), facilitating the global spread of extensive antimicrobial resistance. However, our understanding of the evolutionary dynamics surrounding MGEs, in particular, how changes in the structure of multidrug resistance (MDR) plasmids may influence important staphylococcal phenotypes, is incomplete. Here, we undertook a population and functional genomics study of 212 methicillin-resistant S. aureus (MRSA) sequence type 239 (ST239) isolates collected over 32 years to explore the evolution of the pSK1 family of MDR plasmids, illustrating how these plasmids ha..

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Grants

Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work was funded by the National Health and Medical Research Council, Australia (fellowship GNT1105905, Centres of Research Excellence grant GNT1102962 to B.P.H., and project GNT457454 to N.F. and S.O.J.). S.L.B. was supported by an Australian government research training program scholarship and a Victorian fellowship provided by the Victoria State government.