Journal article
STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction
KM Groom, LM McCowan, LK Mackay, AC Lee, G Gardener, J Unterscheider, R Sekar, JE Dickinson, P Muller, RA Reid, D Watson, A Welsh, J Marlow, SP Walker, J Hyett, J Morris, PR Stone, PN Baker
BJOG an International Journal of Obstetrics and Gynaecology | WILEY | Published : 2019
Abstract
Objective: To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early-onset fetal growth restriction. Design: A randomised placebo-controlled trial. Setting: Thirteen maternal–fetal medicine units across New Zealand and Australia. Population: Women with singleton pregnancies affected by fetal growth restriction at 22+0 to 29+6 weeks. Methods: Women were randomised to oral administration of 25 mg sildenafil citrate or visually matching placebo three times daily until 32+0 weeks, birth or fetal death (whichever occurred first). Main Outcome Measures: The primary outcome was the proportion of pregnancies with an increase in fetal growth velocity. Secondary out..
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Awarded by Health Research Council of New Zealand
Funding Acknowledgements
STRIDER NZAus was funded by a Health Research Council of New Zealand (HRC) project grant 13/242 with additional support for personnel costs from Cure Kids New Zealand 3565. The funders of the trial had no role in trial design, data collection, data analysis, data interpretation or writing of the report.