Journal article

Dorsal language stream anomalies in an inherited speech disorder

Frederique J Liegeois, Samantha J Turner, Angela Mayes, Alexandra F Bonthrone, Amber Boys, Libby Smith, Bronwyn Parry-Fielder, Simone Mandelstam, Megan Spencer-Smith, Melanie Bahlo, Tom S Scerri, Michael S Hildebrand, Ingrid E Scheffer, Alan Connelly, Angela T Morgan

BRAIN | OXFORD UNIV PRESS | Published : 2019

Abstract

Speech disorders are highly prevalent in the preschool years, but frequently resolve. The neurobiological basis of the most persistent and severe form, apraxia of speech, remains elusive. Current neuroanatomical models of speech processing in adults propose two parallel streams. The dorsal stream is involved in sound to motor speech transformations, while the ventral stream supports sound/letter to meaning. Data-driven theories on the role of these streams during atypical speech and language development are lacking. Here we provide comprehensive behavioural and neuroimaging data on a large novel family where one parent and 11 children presented with features of childhood apraxia of speech (t..

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Grants

Awarded by Australian Research Council Discovery Project


Awarded by March of Dimes


Awarded by National Health and Medical Research Council of Australia (Centre for Research Excellence)


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This work was supported by Victorian State Government Operational Infrastructure Support, the Australian Research Council Discovery Project grant (DP120100285), the March of Dimes research grant (12-FY15-3388), and the National Health and Medical Research Council of Australia (Centre for Research Excellence 1116976 and Project grant 1127144) awarded to A.T.M., F.J.L., I.E.S., A.C., M.S.H. and M.B. The work is also supported by the Australian Research Council Discovery Project scheme (DP120100285) awarded to A.T.M., I.E.S., A.C., F.J.L., M.B., and M.H., and by IRIISS funding to the Walter and Eliza Hall Institute of Medical Research (M.B. and T. S.). The National Health and Medical Research Council of Australia provided further support to A.M. (Career Development Fellowship 607315 and Practitioner Fellowship 1105008), S.J.T. (Postgraduate Scholarship 1017773), M.B. (Senior Research Fellowship 1002098 and Program Grant 1054618) and I.E.S. (Program grant 1091593 and Practitioner fellowship 1104831). F.L.'s research is supported by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London (London, UK). S.J.T.'s research is also supported by a Speech Pathology Australia Nadia Verrall Memorial Research grant and Australian National University Gowrie Scholarship.