Journal article

Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data A Scoping Review and Analysis

Tiffany Fitzpatrick, Laure Perrier, Sharara Shakik, Zoe Cairncross, Andrea C Tricco, Lisa Lix, Merrick Zwarenstein, Laura Rosella, David Henry

JAMA NETWORK OPEN | AMER MEDICAL ASSOC | Published : 2018

Abstract

Importance: Follow-up of participants in randomized trials may be limited by logistic and financial factors. Some important randomized trials have been extended well beyond their original follow-up period by linkage of individual participant information to routinely collected data held in administrative records and registries. Objective: To perform a scoping review of randomized clinical trials extended by record linkage to characterize this literature and explore any additional insights into treatment effectiveness provided by long-term follow-up using record linkage. Data Sources: A literature search in Embase, CINAHL, MEDLINE, and the Cochrane Register of Controlled Trials was performed f..

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Grants

Funding Acknowledgements

This research received financial and in-kind support from the Ontario Strategy for Patient-Oriented Research (SPOR) SUPPORT Unit, the Institute for Clinical Evaluative Sciences, and the Ontario Institute for Cancer Research. Drs Tricco, Rosella, and Lix hold Canada Research Chairs.