Journal article

Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

Dean E Sheard, Neil M O'Brien-Simpson, John D Wade, Frances Separovic

PURE AND APPLIED CHEMISTRY | WALTER DE GRUYTER GMBH | Published : 2019

Abstract

The overuse of antibiotics in the healthcare and agricultural industries has led to the worldwide spread of bacterial resistance. The recent emergence of multidrug resistant (MDR) bacteria has resulted in a call for the development of novel strategies to address this global issue. Research on a diverse range of antimicrobial peptides (AMPs) has shown promising activity against several resistant strains. Increased understanding of the mode of action of AMPs has shown similarity and complementarity to conventional antibiotics and the combination of both has led to synergistic effects in some cases. Combination therapy has been widely used to combat MDR bacterial infections and the recent focus..

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