Adverse drug reactions in the gastrointestinal system attributed to ibuprofen

Abstract

Concern about the capacity of non-steroidal anti-inflammatory drugs (NSAIDs) to cause damage to the upper gastrointestinal tract goes back to the 1930s and 1940s when the first associations between ingestion of aspirin and gastrointestinal bleeding were reported [1, 2]. These were relatively small case series but the association was believed to be quite strong, and it was appreciated, even then, that widespread use of aspirin in the community might be responsible for large numbers of cases of gastrointestinal bleeding. The development of newer NSAIDs such as phenylbutazone and indomethacin followed. More recently introduced drugs, such as naproxen and ibuprofen, were thought to have lessened..