Journal article

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS

Steve Simpson, Keryn L Taylor, George A Jelinek, Alysha M De Livera, Chelsea R Brown, Emily O'Kearney, Sandra L Neate, William Bevens, Tracey J Weiland

MULTIPLE SCLEROSIS AND RELATED DISORDERS | ELSEVIER SCI LTD | Published : 2019

Abstract

BACKGROUND: Depression is highly prevalent among people with MS, and determinants thereof would be useful. OBJECTIVES: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS. METHODS: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate. RESULTS: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated..

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