Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS
Steve Simpson, Keryn L Taylor, George A Jelinek, Alysha M De Livera, Chelsea R Brown, Emily O'Kearney, Sandra L Neate, William Bevens, Tracey J Weiland
MULTIPLE SCLEROSIS AND RELATED DISORDERS | ELSEVIER SCI LTD | Published : 2019
BACKGROUND: Depression is highly prevalent among people with MS, and determinants thereof would be useful. OBJECTIVES: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS. METHODS: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate. RESULTS: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated..View full abstract
The study was funded by the Bloom Foundation, Wal Pisciotta, and the Horne Family Charitable Trust. Funding was also received from The Royal Australian and New Zealand College of Psychiatrists, New Investigator Grant (Dr Keryn Taylor).