Survival Mechanisms of Campylobacter hepaticus Identified by Genomic Analysis and Comparative Transcriptomic Analysis of in vivo and in vitro Derived Bacteria
Thu Hao Van Thi, Jake A Lacey, Ben Vezina, Canh Phung, Arif Anwar, Peter C Scott, Robert J Moore
FRONTIERS IN MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2019
Chickens infected with Campylobacter jejuni or Campylobacter coli are largely asymptomatic, however, infection with the closely related species, Campylobacter hepaticus, can result in Spotty Liver Disease (SLD). C. hepaticus has been detected in the liver, bile, small intestine and caecum of SLD affected chickens. The survival and colonization mechanisms that C. hepaticus uses to colonize chickens remain unknown. In this study, we compared the genome sequences of 14 newly sequenced Australian isolates of C. hepaticus, isolates from outbreaks in the United Kingdom, and reference strains of C. jejuni and C. coli, with the aim of identifying virulence genes associated with SLD. We also carried ..View full abstract
SLD related research at RMIT University and Scolexia Pty Ltd is supported by grants from Australian Eggs, Poultry Hub Australia and the Innovation Connections scheme of the Australian Commonwealth Government.