Dose-dependent exacerbation of ventilation-induced lung injury by erythropoietin in preterm newborn lambs

Abstract

Allison BJ, LaRosa DA, Barton SK, Hooper S, Zahra V, Tolcos M, Chan KY, Barbuto J, Inocencio IM, Moss TJ, Polglase GR. Dose-dependent exacerbation of ventilation-induced lung injury by erythropoietin in preterm newborn lambs. J Appl Physiol 126: 44 –50, 2019. First published November 1, 2018; doi:10.1152/jappl-physiol.00800.2018.—Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilated preterm lambs. We aimed to determine whether early administration of lower doses of EPO could reduce ventilation-induced lung injury and systemic inflammation in preterm lambs. Ventilation was initiated in anaesthetized preterm lambs [1..