Journal article

Deciphering the role of DC subsets in MCMV infection to better understand immune protection against viral infections

Yannick O Alexandre, Clement D Cocita, Sonia Ghilas, Marc Dalod

Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2014

Abstract

Infection of mice with murine cytomegalovirus (MCMV) recapitulates many physiopathological characteristics of human CMV infection and enables studying the interactions between a virus and its natural host. Dendritic cells (DC) are mononuclear phagocytes linking innate and adaptive immunity which are both necessary for MCMV control. DC are critical for the induction of cellular immunity because they are uniquely efficient for the activation of naïve T cells during their first encounter with a pathogen. DC are equipped with a variety of innate immune recognition receptors (I2R2) allowing them to detect pathogens or infections and to engulf molecules, microorganisms or cellular debris. The comb..

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Grants

Awarded by l'Agence Nationale de la Recherche


Awarded by Fondation pour la Recherche Medicate


Awarded by European Research Council under the European Community's Seventh Framework Programme



Funding Acknowledgements

The studies performed in the laboratory of Marc Dalod are supported by institutional funding from INSERM, CNRS, and Aix-Marseille-University, grants from l'Agence Nationale de la Recherche (ANR-08-MIEN-008-02), from Fondation pour la Recherche Medicate (label "Equipe FRM 2011,"project number DEQ20110421284) and from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013 Grant Agreement number 281225). Yannick O.Alexandre was supported by a doctoral fellowship from the French Ministere de l'Enseignement Superieur et de la Recherche, and from Association pour la recherche sur le cancer (ARC). Sonia Ghilas was laureate from a "University President" Excellence Ph.D. Fellowship (Aix-Marseille-University). Clement D. Cocita was supported through the DEQ20110421284 FRM grant to Marc Dalod. We thank all the past and present members of the laboratory for their contribution to studies on the role of DC and NK cells in antiviral defense. Because of space limitations, certain studies could not be quoted. We apologize to colleagues for such omissions. Schematic representations of cells and virus are adapted from Servier Medical Art Powerpoint image bank (smart.servier.fr/servier-medical-art).