Existence of CD8α-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species.
Vanessa Contreras, Céline Urien, Rachel Guiton, Yannick Alexandre, Thien-Phong Vu Manh, Thibault Andrieu, Karine Crozat, Luc Jouneau, Nicolas Bertho, Mathieu Epardaud, Jayne Hope, Ariel Savina, Sebastian Amigorena, Michel Bonneau, Marc Dalod, Isabelle Schwartz-Cornil
J Immunol | Published : 2010
The mouse lymphoid organ-resident CD8alpha(+) dendritic cell (DC) subset is specialized in Ag presentation to CD8(+) T cells. Recent evidence shows that mouse nonlymphoid tissue CD103(+) DCs and human blood DC Ag 3(+) DCs share similarities with CD8alpha(+) DCs. We address here whether the organization of DC subsets is conserved across mammals in terms of gene expression signatures, phenotypic characteristics, and functional specialization, independently of the tissue of origin. We study the DC subsets that migrate from the skin in the ovine species that, like all domestic animals, belongs to the Laurasiatheria, a distinct phylogenetic clade from the supraprimates (human/mouse). We demonstra..View full abstract