Journal article

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2019

Abstract

Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating or repressing gene transcription in mice and humans. The role of SATB1 is pivotal for T-cell development, with SATB1-knockout mice being neonatally lethal, although the exact mechanism is unknown. Moreover, SATB1 is dysregulated in T-cell lymphoma and proposed to suppress transcription of the Pdcd1 gene, encoding the immune checkpoint programmed cell death protein 1 (PD-1). Thus, SATB1 expression in T-cell subsets across different tissue compartments in humans is of potential importance for targeting PD-1. Here, we comprehensively analyzed SATB1 expression across different human tissues and immune..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Awarded by JDRF Career Development Award


Funding Acknowledgements

SN is supported by a Melbourne International Research Scholarship (MIRS) and Melbourne International Fee Remission Scholarship (MIFRS). The Australian National Health and Medical Research Council (NHMRC) Program Grants (1071916) to KK and SJT and (1113293) to DIG supported this work. KK is an NHMRC Senior Research Level B Fellow (1102792). SJT is an NHMRC Principal Research Fellow (APP1103895). HFK is supported by an NHMRC Early Career Fellowship (1160333). EBC and HFK are NHMRC Peter Doherty Fellows. DIG is supported by an NHMRC Senior Principal Research Fellowship (1117766). SM is supported by a JDRF Career Development Award (5C-DA2014210-A-N). ML is supported by a Research Fellowship from the Department of Obstetrics and Gynaecology and a Faculty Fellowship, both from the University of Melbourne. We thank the clinical research midwives Gabrielle Pell, Genevieve Christophers and Rachel Murdoch for cord blood sample collection; and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their cooperation.