Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework
Jeremy MC Brown, Gerard G Hanna, Nathanael Lampe, Balder Villagomez-Bernabe, James R Nicol, Jonathan A Coulter, Fred J Currell
CANCER NANOTECHNOLOGY | BMC | Published : 2018
A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and high Z NP-doped adult female phantom. Application of the RBED framework found..View full abstract
Awarded by EPSRC
This work was supported by EPSRC grant EP/K039342/1; and the Multi-modal Australian ScienceS Imaging and Visualization Environment (MASSIVE) (http://www.massive.org.au).